People born in 2001， under the sign of the Snake， may encounter three significant challenges in their lifetime. These劫难 (jié nàn， tribulations or calamities) can be related to different aspects of life， such as relationships， career， and health.

Here's a summary of the potential劫难:

Relationship Tribulation: For individuals born in 2001， a major relationship tribulation may involve marital issues. Their pursuit of perfection can lead to a lack of confidence in marriage and emotional relationships， significantly impacting their future. These individuals may be prone to experiencing "桃花劫" (táo huā jié， literally "peach blossom tribulation")， especially around the age of 28. This refers to emotional challenges caused by an abundance of romantic interests， often leading to negative experiences. To avoid these劫难， it's advisable to be decisive in relationships， avoid ambiguity， and practice self-respect. Wearing peach wood ornaments is believed to help ward off negative relationships and foster positive connections.

Career Crisis: In their career， those born in 2001 may face a劫难 related to their wealth. They might experience job loss due to personal errors in the workplace， leading to unstable income.

Health Crisis: Around the age of 60， individuals born in 2001 may encounter significant health problems. These problems can arise from neglecting their health in their younger years and enduring long-term work stress， which can affect their work， relationships， and even lead to marital breakdown.